Neuro Thrombectomy
System

Penumbra’s market-leading neuro thrombectomy platform is designed to remove clot from the neurovasculature during an acute ischemic stroke using a combination of intentionally sized reperfusion catheters and deep vacuum.

Penumbra’s CAVT™​ (Computer Assisted Vacuum Thrombectomy) platform, introduced to Neuro in 2026, utilizes advanced computer technology designed to enable rapid restoration of blood flow through a minimally invasive approach. The CAVT platform harnesses the power of the Penumbra ENGINE^® Aspiration Source, which delivers nearly pure, continuous vacuum (-29.2 inHg or -98.9 kPa) in combination with atmospheric pressure designed to effectively fatigue and ingest clot.

CAVT is designed to assist in rapid clot detection and ingestion at the site of the occlusion. This is achieved by introducing Modulated Aspiration, designed to help manage friction between the catheter and clot.

The CAVT platform leverages proprietary computer algorithms designed to:

• Detect clot via internal pressure sensors
• Fatigue clot via modulated aspiration
• Ingest clot at the site of the occlusion

The Penumbra System represents the foundation of the neuro thrombectomy portfolio. The system is comprised of the ENGINE Aspiration Source and is compatible with all Penumbra reperfusion catheters. The Penumbra System:

• Generates nearly pure vacuum (-29.2 Hg or 98.9 kPa)
• Includes integrated clot catcher and disposable canister
• Compatible with all Penumbra System Reperfusion Catheters
• ENGINE, RED 62, RED 68, RED 72, and RED 72 with SENDit Technology are compatible with CAVT