CHEETAH STUDY RESULTS
Prospective
400
Patients
25
Sites
High Thrombus Burden in ACS
CHEETAH Study:
Demonstrate the safety and performance of the Indigo® Aspiration System using the CAT™ RX aspiration catheter in a population presenting with acute high thrombus burden coronary vessel occlusion who are referred for Percutaneous Coronary Intervention (PCI)
Read more in Circulation: Cardiovascular Interventions
Precaution: The safety and effectiveness of this device for use in the treatment of ST-Elevation Myocardial Infarction (STEMI) has not been established. Complications from the use of this device in this manner could lead to death, permanent impairment, and/or the need for emergency medical intervention.
Published in Circ CI1
Primary Composite Endpoint Met
Safe in High-Risk Patient Population
96.5%
Freedom from MACE at 30 daysa
0
Device related SAEs (including strokeb)
Successful Thrombus Removal
High Rates of Flow Achieved
85%
TIMI 2-3 flow post-CAT RX
97.5%
TIMI 3 flow at final angiography
Low Distal Embolization Rate
Improved Myocardial Perfusion
Achieving high myocardial blush grade (MBG 3) during PCI has been associated with improved outcomes in acute MI3
Power aspiration with CAT RX is safe for removal of high thrombus burden with low rates of distal embolization and improved myocardial perfusion
a. Composite of 30 day cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening New York Heart Association Class IV heart failure.
b. There were 3 (.75%) incidence of non-device related strokes as IMR adjudicated.
1. Mathews SJ, et al. Sustained mechanical aspiration thrombectomy for high thrombus burden coronary vessel occlusion: the multicenter CHEETAH Study. Circ Cardiovasc Interv. 2023 Feb;16(2):e012433. doi: 10.1161/CIRCINTERVENTIONS.122.012433.
2. Henriques JPS, Zijlstra F, Ottervanger JP, et al. Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction. Eur Heart J. 2002 Jul;23(14):1112–1117. doi: 10.1053/euhj.2001.3035.
3. Rehman A, Malik J, Javed N, Iftikhar I, Sharif H. Myocardial blush grade: a determinant of left ventricular ejection fraction and adverse outcomes in STEMI. Scott Med J. 2021 Feb;66(1):34–39. doi: 10.1177/0036933020941260.
The clinical results presented herein are for informational purposes only, and may not be predictive for all patients. Individual results may vary depending on patient-specific attributes and other factors.
