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Penumbra Inc.'s ischemic stroke device platform, the Penumbra System®, is designed to revascularize or open up a blood vessel that is blocked by a blood clot. The pathology of brain tissue starved of oxygen by a blocked blood vessel is a gradual progression from reversible ischemia to irreversible infarction (cell death).

The penumbra, a rim of ischemic but still viable tissue that surrounds a central core of infarction, has consistently been shown in animal models to be salvageable if blood flow can be restored within a certain time window. Data from human studies with surrogate measurements of cell viability tended to support this hypothesis. Thus, current treatment strategy for ischemic stroke is based on an urgent restoration of blood flow to the ischemic penumbra within a time window to prevent the permanent loss of brain cells, leading to improved outcome for the patient.

Currently there is only one FDA-approved treatment for an acute ischemic stroke: intravenous (IV) delivery of Tissue Plasminogen Activator (t-PA) (Activase), which is a thrombolytic agent. The agent is designed to dissolve the blood clot that is blocking blood flow to the brain. IV t-PA is currently limited in use since it must be used within a 3-hour window from the onset of the stroke and it appears to carry an increased risk of bleeding.

An option beyond the 3-hour window is a thromboembolectomy device. Penumbra's device has been designed taking into account many of the variables and complications that have prevented other devices from working well in this area.

The Penumbra System is FDA cleared and CE–marked. It is available for sale in the United States, Europe, Japan, and many other parts of the world.





Hemorrhagic stroke is a result of a rupture of a blood vessel within the brain. The hemorrhage can be caused by an aneurysm (weakened blood vessel wall), vascular malformation, hypertension, or from a traumatic event.

One type of hemorrhage is a subarachnoid hemorrhage where bleeding occurs in the space between the brain and the cranium in an area called the subarachnoid space. This type of hemorrhage is usually observed when an aneurysm ruptures.

Coil embolization is a procedure that stops abnormal blood flow in the weakened, bubble-shaped wall of a blood vessel. A catheter with a fine metal coil is inserted into the femoral artery at the groin. It is then guided to the aneurysm in the brain. Once properly positioned, the coil is released within the aneurysm. Blood clot forms naturally around the coil, preventing further abnormal blood flow inside the aneurysm. Eventually, a scar forms a permanent seal.

Penumbra Coil 400™ is FDA cleared and CE–marked. It is available for sale in the United States, Europe and other parts of the world.




Penumbra’s pioneering Neuron™ 053 Delivery Catheter was the first family of highly flexible guide catheters capable of distal placement to the petro-cavernous segments. The novel Neuron 053 design includes a tapered shaft from 6F to 5F, a full length coil reinforced shaft, and hydrophilic coating. The first publication reviewing the initial clinical experience in Neurosurgery captured the essence of this innovation with the authors and commentators both concluding that a breakthrough was needed to improve on conventional guide catheter technology and that the Neuron 053 enabled distal catheterization of the intracranial vasculature with added stability and support.

Building on the innovative approach used with the Neuron 053, Penumbra further re-defined access with larger lumen devices that built on the 053 concept of distal placement for added stability and support with the Neuron 070 and NeuronMAX 088. A recent review of these technologies from the 2013 Val d’Isère meeting can be found here.

The latest Penumbra access technologies include the 5MAX DDC, Velocity and PX SLIM which all integrate Penumbra’s MAX tracking technology with highly trackable nitinol reinforced shafts with lumens from .025” to .062”.


Please contact your local Penumbra representative if you have any questions.




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